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Channel: Anesthesiology: Pharmacology Topic Collection
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Propofol and Sevoflurane Differentially Impact MicroRNAs in Circulating...

Editor’s Perspective What We Already Know about This Topic While total intravenous anesthesia in combination with local-regional anesthesia during cancer resection may result in improved outcomes,...

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Transversus Abdominis Plane Block A Narrative Review

In this narrative review article, the authors discuss the anatomy, nomenclature, history, approaches (posterior vs. lateral vs. subcostal), techniques, pharmacology, indications, and complications of...

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Genetic Analysis of Patients Who Experienced Awareness with Recall while...

Editor’s Perspective What We Already Know about This Topic The incidence of explicit recall of intraoperative events, or awareness with recall, is less than 0.2%Anesthetic dosing is apparently...

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Be Wary of Genes Governing Awareness

“[G]enetic data…do not identify a single protein that is uniquely responsible for awareness under anesthesia.”

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Upper Airway Collapsibility during Dexmedetomidine and Propofol Sedation in...

Editor’s Perspective What We Already Know about This Topic Dexmedetomidine is a relatively new sedative promoted as having minimal effect on ventilatory drive or the propensity to upper airway...

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Pharmacodynamic Interaction of Remifentanil and Dexmedetomidine on Depth of...

Editor’s Perspective What We Already Know about This Topic Patients sedated with standard clinical doses of dexmedetomidine can be readily arousedDexmedetomidine doses producing mild to deep sedation...

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Early Postnatal Exposure to Isoflurane Disrupts Oligodendrocyte Development...

Editor’s Perspective What We Already Know about This Topic Oligodendrocyte proliferation and maturation are prerequisites for myelination in the central nervous system. Disruption of these processes...

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Reporting Laboratory and Animal Research in A nesthesiology The Importance of...

“Consideration of sex as a biologic variable in conducting laboratory animal research—and inclusion of both sexes—is strongly encouraged.”

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Intergenerational Effects of Sevoflurane in Young Adult Rats

Editor’s Perspective What We Already Know about This Topic Exposure to environmental stressors and endocrine disruptors can induce multigenerational effects resulting in neurobehavioral and other...

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Dexmedetomidine and the Upper Airway Not as Simple as We Hoped

“Breathing is truly a strange phenomenon of life, caught between the conscious and the unconscious, and peculiarly sensitive to both”1 “[D]exmedetomidine seems to cause no less propensity for airway...

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Effect of a Cognitive Aid on Reducing Sugammadex Use and Associated Costs A...

Editor’s Perspective What We Already Know about This Topic Sugammadex provides rapid and effective reversal of neuromuscular blocks but is expensive What This Article Tells Us That Is New The...

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Safe Sedation Re-examined: Comparing the Respiratory Effects of...

Complex Information for Anesthesiologists Presented Quickly and Clearly

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Anesthetic Management Using Multiple Closed-loop Systems and Delayed...

Editor’s PerspectiveWhat We Already Know about This TopicRecommendations for anesthetic care are often difficult to implement in the intraoperative setting because of the requirement for continuous...

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Information Integration and Mesoscopic Cortical Connectivity during Propofol...

Editor’s PerspectiveWhat We Already Know about This TopicCoupling of neuronal oscillations between brain regions is correlated with higher level brain activityPermutation cross mutual information can...

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Population Pharmacodynamics of Propofol and Sevoflurane in Healthy Volunteers...

Editor’s PerspectiveWhat We Already Know about This TopicHypnotic drug effects can be assessed as the presence or absence of standard clinical endpoints, such as tolerance to calling the person by name...

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Drug-selective Anesthetic Insensitivity of Zebrafish Lacking γ-Aminobutyric...

Editor’s PerspectiveWhat We Already Know about This Topicβ3 subunits of the γ-aminobutyric acid type A (GABAA) receptor play a central role in mediating hypnotic and sedative effects of etomidate,...

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The Art of General Anesthesia Juggling in a Multidimensional Space

“[How does] the addition of an opioid drug (remifentanil) alter responses to…propofol and sevoflurane?”

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Analgesic and Respiratory Depressant Effects of R-dihydroetorphine A...

Editor’s PerspectiveWhat We Already Know about This TopicOpioid agonists acting at the nociception/orphanin FQ, δ-opioid, and κ-opioid receptors may counteract respiratory depression induced by...

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Sevoflurane Promotes Bactericidal Properties of Macrophages through Enhanced...

Editor’s PerspectiveWhat We Already Know about This TopicSevoflurane has antiinflammatory properties, but less is known about effects on infectious inflammationSevoflurane effects on macrophage...

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Multi-Dimensional Anesthesia: The Effects of Sevoflurane or Propofol with...

Complex Information for Anesthesiologists Presented Quickly and Clearly

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