Propofol and Sevoflurane Differentially Impact MicroRNAs in Circulating...
Editor’s Perspective What We Already Know about This Topic While total intravenous anesthesia in combination with local-regional anesthesia during cancer resection may result in improved outcomes,...
View ArticleTransversus Abdominis Plane Block A Narrative Review
In this narrative review article, the authors discuss the anatomy, nomenclature, history, approaches (posterior vs. lateral vs. subcostal), techniques, pharmacology, indications, and complications of...
View ArticleGenetic Analysis of Patients Who Experienced Awareness with Recall while...
Editor’s Perspective What We Already Know about This Topic The incidence of explicit recall of intraoperative events, or awareness with recall, is less than 0.2%Anesthetic dosing is apparently...
View ArticleBe Wary of Genes Governing Awareness
“[G]enetic data…do not identify a single protein that is uniquely responsible for awareness under anesthesia.”
View ArticleUpper Airway Collapsibility during Dexmedetomidine and Propofol Sedation in...
Editor’s Perspective What We Already Know about This Topic Dexmedetomidine is a relatively new sedative promoted as having minimal effect on ventilatory drive or the propensity to upper airway...
View ArticlePharmacodynamic Interaction of Remifentanil and Dexmedetomidine on Depth of...
Editor’s Perspective What We Already Know about This Topic Patients sedated with standard clinical doses of dexmedetomidine can be readily arousedDexmedetomidine doses producing mild to deep sedation...
View ArticleEarly Postnatal Exposure to Isoflurane Disrupts Oligodendrocyte Development...
Editor’s Perspective What We Already Know about This Topic Oligodendrocyte proliferation and maturation are prerequisites for myelination in the central nervous system. Disruption of these processes...
View ArticleReporting Laboratory and Animal Research in A nesthesiology The Importance of...
“Consideration of sex as a biologic variable in conducting laboratory animal research—and inclusion of both sexes—is strongly encouraged.”
View ArticleIntergenerational Effects of Sevoflurane in Young Adult Rats
Editor’s Perspective What We Already Know about This Topic Exposure to environmental stressors and endocrine disruptors can induce multigenerational effects resulting in neurobehavioral and other...
View ArticleDexmedetomidine and the Upper Airway Not as Simple as We Hoped
“Breathing is truly a strange phenomenon of life, caught between the conscious and the unconscious, and peculiarly sensitive to both”1 “[D]exmedetomidine seems to cause no less propensity for airway...
View ArticleEffect of a Cognitive Aid on Reducing Sugammadex Use and Associated Costs A...
Editor’s Perspective What We Already Know about This Topic Sugammadex provides rapid and effective reversal of neuromuscular blocks but is expensive What This Article Tells Us That Is New The...
View ArticleSafe Sedation Re-examined: Comparing the Respiratory Effects of...
Complex Information for Anesthesiologists Presented Quickly and Clearly
View ArticleAnesthetic Management Using Multiple Closed-loop Systems and Delayed...
Editor’s PerspectiveWhat We Already Know about This TopicRecommendations for anesthetic care are often difficult to implement in the intraoperative setting because of the requirement for continuous...
View ArticleInformation Integration and Mesoscopic Cortical Connectivity during Propofol...
Editor’s PerspectiveWhat We Already Know about This TopicCoupling of neuronal oscillations between brain regions is correlated with higher level brain activityPermutation cross mutual information can...
View ArticlePopulation Pharmacodynamics of Propofol and Sevoflurane in Healthy Volunteers...
Editor’s PerspectiveWhat We Already Know about This TopicHypnotic drug effects can be assessed as the presence or absence of standard clinical endpoints, such as tolerance to calling the person by name...
View ArticleDrug-selective Anesthetic Insensitivity of Zebrafish Lacking γ-Aminobutyric...
Editor’s PerspectiveWhat We Already Know about This Topicβ3 subunits of the γ-aminobutyric acid type A (GABAA) receptor play a central role in mediating hypnotic and sedative effects of etomidate,...
View ArticleThe Art of General Anesthesia Juggling in a Multidimensional Space
“[How does] the addition of an opioid drug (remifentanil) alter responses to…propofol and sevoflurane?”
View ArticleAnalgesic and Respiratory Depressant Effects of R-dihydroetorphine A...
Editor’s PerspectiveWhat We Already Know about This TopicOpioid agonists acting at the nociception/orphanin FQ, δ-opioid, and κ-opioid receptors may counteract respiratory depression induced by...
View ArticleSevoflurane Promotes Bactericidal Properties of Macrophages through Enhanced...
Editor’s PerspectiveWhat We Already Know about This TopicSevoflurane has antiinflammatory properties, but less is known about effects on infectious inflammationSevoflurane effects on macrophage...
View ArticleMulti-Dimensional Anesthesia: The Effects of Sevoflurane or Propofol with...
Complex Information for Anesthesiologists Presented Quickly and Clearly
View Article